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Valtrex is an oral antiviral medicine used for a number of herpes viruses that cause cold sores (herpes labialis), shingles (herpes zoster) and genital herpes (herpes simplex genitalis). It's most efficient against the symptoms caused by the spread of those viruses when taken within the first 48 hours from the moment the first signs of the infection appeared. Valtrex is usually taken for up to a week depending on the specific condition being treated: it's usually 5 days for treating cases of recurrent herpes (500 mg dose), 10 days for an initial spidoe of herpes and 7 days for shingles. Valtrex is not a cure for the infection,. Rather than a way to keep it under control.